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Safety Considerations for Repeated Use Repeatedly piercing a vial with a needle introduces a small risk of bacterial contamination each time, regardless of which water is used

However, limitations included the restricted inclusion criteria (eGFR range of 2075 mL/min/1.73 m 2 and albuminuria requirements), which limit generalizability to patients with higher or lower eGFR or preserved eGFR without albuminuria

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The GetGoal-X trial compared the efficacy and safety of lixisenatide to exenatide twice daily in patients with uncontrolled T2D on metformin [Rosenstock et al

Am J Gastroenterol 117:21802181

Elevated intracellular calcium is considered important in stimulating secretory vesicles, which may lead to growth hormone release and subsequent signaling through insulin-like growth factor 1 (IGF-1)